Here are the links to my initial discussions:
- Tuning Very Large SQL-Server Databases - Part 1 (Physical Storage Optimization)
- SQL Server - Optimization: Tuning Very Large SQL-Server Databases - Part 2 - Database Storage and Performance (continued)
If you find these useful, and/or want more detail about any aspect of the discussions, just let me know. After helping all sorts of companies tune their massive SQL relational databases, I know one thing is a fact: most huge databases can benefit from a bit of common-sense tuning. So, start by reading these performance tips, and realize some performance benefits right away.